Mr. Kalipada Manna
Kalipada Manna is a native of Purba Medinipur, West Bengal, India. He obtained his BSc and MSc degrees from Vidyasagar University in 2014 and 2016, respectively. Currently, he is pursuing his PhD under the supervision of Dr. Sagar Pal at the Indian Institute of Technology (ISM) in Dhanbad. His research interests include the synthesis of new polymeric materials and their applications.
Research Area
Polymeric Micelles
Polymeric micelles are self-assembled nanostructures formed from amphiphilic block copolymers, offering a versatile platform for drug delivery and biomedical applications.
Blueprint
Amphiphilic Polymers
Polymeric micelles are composed of amphiphilic block copolymers with a hydrophilic and a hydrophobic segment.
Controlled Parameters
Factors like polymer concentration, molecular weight, and block ratio can be tuned to control micelle size, stability, and drug loading capacity.
Self-Assembly
In aqueous environments, the hydrophobic blocks associate to minimize contact with water, forming the core, while the hydrophilic blocks form the outer shell.
Physicochemical Properties
Small Size
Polymeric micelles typically range from 10 to 100 nm in diameter, enabling efficient accumulation in tumors via the enhanced permeability and retention (EPR) effect.
Core-Shell Structure
The hydrophobic core can solubilize and protect hydrophobic drugs, while the hydrophilic shell provides stealth properties and stability in the bloodstream.
Stimuli-Responsiveness
Micelles can be designed to respond to environmental cues like pH, temperature, or enzymes, triggering drug release at the target site.
Therapeutic Delivery Applications
Cancer Therapy
Polymeric micelles can enhance the solubility, stability, and selective accumulation of hydrophobic anticancer drugs in solid tumors.
Gene and Protein Delivery
Micelles can encapsulate and protect sensitive biomacromolecules, facilitating their safe delivery to target cells and tissues.
Antimicrobial Agents
Micelle-based formulations can boost bioavailability and efficacy of hydrophobic antimicrobials.
Theranostics
Multifunctional micelles can integrate diagnostic and therapeutic capabilities for personalized medicine and image-guided drug delivery.
Research Activity
Published Journal
